Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
نویسندگان
چکیده
Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3-28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Nav1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Nav1.7 might play an important role in the model of chronic neuropathic pain.
منابع مشابه
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2012